Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.

@article{Escano2008AngiotensinIA,
  title={Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.},
  author={Crisanto S. Escano and Lindsay B. Keever and Alexander A Gutweiler and Bradley T. Andresen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={324 1},
  pages={
          34-42
        }
}
Angiotensin II can cause hypertension through enhanced vasoconstriction of renal vasculature. One proposed mechanism for reduction of angiotensin II-induced hypertension is through inhibition of the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase cascade. MEK/ERK has been shown to phosphorylate the regulatory subunit of myosin light chain at identical positions as myosin light chain kinase. There are multiple mechanisms… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 47 references

The role of Rho kinase and extracellular regulated kinasemitogen-activated protein kinase in 2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein

  • RE Roberts
  • J Pharmacol Exp Ther 311:742–747
  • 2004
Highly Influential
6 Excerpts

Role of EGFR

  • BT 56–60. Andresen, JJ Linnoila, EK Jackson, GG Romero
  • 2003
Highly Influential
4 Excerpts

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