Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels.

@article{Sampson2007AngiotensinIP,
  title={Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels.},
  author={Laura J Sampson and Lowri M Davies and Richard Barrett-Jolley and Nick B Standen and Caroline Dart},
  journal={Cardiovascular research},
  year={2007},
  volume={76 1},
  pages={61-70}
}
OBJECTIVE The vasoconstrictor angiotensin II (Ang II) acts at G(q/11)-coupled receptors to suppress ATP-sensitive potassium (K(ATP)) channel activity via activation of protein kinase C (PKC). The aim of this study was to determine the PKC isoforms involved in the Ang II-induced inhibition of aortic K(ATP) channel activity and to investigate potential mechanisms by which these isoforms specifically target these ion channels. METHODS AND RESULTS We show that the inhibitory effect of Ang II on… CONTINUE READING