Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis.

@article{Mackenzie2013AngiotensinIT,
  title={Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis.},
  author={Andrew Mackenzie and Lynette Dunning and William Russell Ferrell and John C. Lockhart},
  journal={Life sciences},
  year={2013},
  volume={92 23},
  pages={1131-7}
}
AIMS Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. Impaired endothelial cell (EC) function and elevated angiotensin II levels may be central to the link between vascular dysfunction and RA. Here we investigated the action of angiotensin type 1 receptor (AT1R) blockade on endothelium-dependent relaxation of the isolated saphenous artery in a rat model of monoarthritis. MAIN METHODS Adjuvant arthritis was induced in rats with and without prophylactic losartan (AT1R… CONTINUE READING