Angiotensin II Type 1 and Type 2 Receptors Regulate Basal Skeletal Muscle Microvascular Volume and Glucose Use

@article{Chai2010AngiotensinIT,
  title={Angiotensin II Type 1 and Type 2 Receptors Regulate Basal Skeletal Muscle Microvascular Volume and Glucose Use},
  author={W. Chai and W. Wang and J. Liu and E. Barrett and R. Carey and W. Cao and Z. Liu},
  journal={Hypertension},
  year={2010},
  volume={55},
  pages={523-530}
}
  • W. Chai, W. Wang, +4 authors Z. Liu
  • Published 2010
  • Medicine
  • Hypertension
  • Angiotensin II causes vasoconstriction via the type 1 receptor (AT1R) and vasodilatation through the type 2 receptor (AT2R). Both are expressed in muscle microvasculature, where substrate exchanges occur. Whether they modulate basal muscle microvascular perfusion and substrate metabolism is not known. We measured microvascular blood volume (MBV), a measure of microvascular surface area and perfusion, in rats during systemic infusion of angiotensin II at either 1 or 100 ng/kg per minute. Each… CONTINUE READING

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