Angiotensin II Regulates the Expression of Monocyte Chemoattractant Protein-1 in Pancreatic Cancer Cells

@article{Chehl2009AngiotensinIR,
  title={Angiotensin II Regulates the Expression of Monocyte Chemoattractant Protein-1 in Pancreatic Cancer Cells},
  author={Navdeep Chehl and Qiaoke Gong and Galina Chipitsyna and Tamer Aziz and Charles J Yeo and Hwyda A Arafat},
  journal={Journal of Gastrointestinal Surgery},
  year={2009},
  volume={13},
  pages={2189-2200}
}
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers with an overall median survival of less than 9 months and a 5-year survival rate of less than 5%. Increasing evidence indicates that inflammation facilitates PDA growth. Angiotensin II (AngII), the principal hormone of the renin–angiotensin system, is actively generated in the pancreas and has been proposed as a key mediator of inflammation. Monocyte chemoattractant protein (MCP)-1 is a chemokine that plays an important… CONTINUE READING