Angiotensin II Infusion Induces Marked Diaphragmatic Skeletal Muscle Atrophy

@inproceedings{Rezk2012AngiotensinII,
  title={Angiotensin II Infusion Induces Marked Diaphragmatic Skeletal Muscle Atrophy},
  author={Bashir M. Rezk and Tadashi Yoshida and Laura C Semprun-Prieto and Yusuke Higashi and Sergiy Sukhanov and Patrice Delafontaine},
  booktitle={PloS one},
  year={2012}
}
Advanced congestive heart failure (CHF) and chronic kidney disease (CKD) are characterized by increased angiotensin II (Ang II) levels and are often accompanied by significant skeletal muscle wasting that negatively impacts mortality and morbidity. Both CHF and CKD patients have respiratory muscle dysfunction, however the potential effects of Ang II on respiratory muscles are unknown. We investigated the effects of Ang II on diaphragm muscle in FVB mice. Ang II induced significant diaphragm… CONTINUE READING

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