Angiotensin II Induces Premature Senescence of Vascular Smooth Muscle Cells and Accelerates the Development of Atherosclerosis via a p 21-Dependent Pathway

@inproceedings{Kunieda2006AngiotensinII,
  title={Angiotensin II Induces Premature Senescence of Vascular Smooth Muscle Cells and Accelerates the Development of Atherosclerosis via a p 21-Dependent Pathway},
  author={Takeshige Kunieda and Tohru Minamino and Junichiro Nishi and Kaoru Tateno and Tomomi Oyama and Taro Katsuno and Hideyuki Miyauchi and Masayuki Orimo and Sho Okada and Masayuki Takamura and Toshio Nagai and Shuichi Kaneko and Issei Komuro},
  year={2006}
}
Background—Angiotensin II (Ang II) has been reported to contribute to the pathogenesis of various human diseases including atherosclerosis, and inhibition of Ang II activity has been shown to reduce the morbidity and mortality of cardiovascular diseases. We have previously demonstrated that vascular cell senescence contributes to the pathogenesis of atherosclerosis; however, the effects of Ang II on vascular cell senescence have not been examined. Methods and Results—Ang II significantly… CONTINUE READING

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