Angiotensin II AT2 receptors do not interact with guanine nucleotide binding proteins.

@article{Bottari1991AngiotensinIA,
  title={Angiotensin II AT2 receptors do not interact with guanine nucleotide binding proteins.},
  author={Serge Pierre Bottari and Vivienne Taylor and Isabelle N King and Y Bogdal and Steven Whitebread and Marc de Gasparo},
  journal={European journal of pharmacology},
  year={1991},
  volume={207 2},
  pages={157-63}
}
We have studied the effect of GTP gamma S on the affinity and binding kinetics of angiotensin II in plasma membrane particulate prepared from tissues expressing either only AT1 (human renal artery smooth muscle cells), only AT2 (human myometrium and bovine cerebellar cortex) or both angiotensin II receptor subtypes (rat adrenal glomerulosa). We also examined the ability of angiotensin II to stimulate GTP gamma[35S] incorporation in these membrane preparations. In contrast to its effects on… CONTINUE READING