Angiotensin II AT1 receptor constitutive activation: from molecular mechanisms to pathophysiology.

@article{Petrel2009AngiotensinIA,
  title={Angiotensin II AT1 receptor constitutive activation: from molecular mechanisms to pathophysiology.},
  author={Christophe Petrel and Eric Clauser},
  journal={Molecular and cellular endocrinology},
  year={2009},
  volume={302 2},
  pages={176-84}
}
Mutations activating the angiotensin II AT(1) receptor are important to identify and characterize because they give access to the activation mechanisms of this G protein coupled receptor and help to characterize the signaling pathways and the potential pathophysiology of this receptor. The different constitutively activated mutations of the AT(1) receptor are mostly localized in transmembrane domains (TM) and their characterization demonstrated that release of intramolecular constraints and… CONTINUE READING

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