Angiotensin II AT1 receptor constitutive activation: from molecular mechanisms to pathophysiology.

  title={Angiotensin II AT1 receptor constitutive activation: from molecular mechanisms to pathophysiology.},
  author={Christophe Petrel and Eric Clauser},
  journal={Molecular and cellular endocrinology},
  volume={302 2},
Mutations activating the angiotensin II AT(1) receptor are important to identify and characterize because they give access to the activation mechanisms of this G protein coupled receptor and help to characterize the signaling pathways and the potential pathophysiology of this receptor. The different constitutively activated mutations of the AT(1) receptor are mostly localized in transmembrane domains (TM) and their characterization demonstrated that release of intramolecular constraints and… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations

Adhesion ability of angiotensin II with model membranes.

Biochimica et biophysica acta. Biomembranes • 2017
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 49 references

Activation of the angiotensin II type 1 receptor leads to movement of the sixth transmembrane domain: analysis by the substituted cysteine accessibility method

S. S. artin, B. J. Holleran, E. Escher, G. Guillemette, R. Leduc
Mol. Pharmacol • 2007

Role of the Cys18–Cys274 disulfide bond and of the third extracellular loop in the constitutive activation and internalization of angiotensin II type 1 receptor

S. A. orrea, G. C. Pignatari, +6 authors S. I. Shimuta
Regul. Pept • 2006

Molecular mechanisms of constitutive activity: mutations at position 111 of the angiotensin AT1 receptor

G. V. ikiforovich, B. Mihalik, K. J. Catt, G. R. Marshall
J. Pept. Res • 2005

Similar Papers

Loading similar papers…