Angiotensin II AT(1) blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats.

@article{Nishimura2000AngiotensinIA,
  title={Angiotensin II AT(1) blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats.},
  author={Yasuaki Nishimura and Takeshi Ito and J M Saavedra},
  journal={Stroke},
  year={2000},
  volume={31 10},
  pages={2478-86}
}
BACKGROUND AND PURPOSE Angiotensin II, through stimulation of AT(1) receptors, not only controls blood pressure but also modulates cerebrovascular flow. We sought to determine whether selective AT(1) antagonists could be therapeutically advantageous in brain ischemia during chronic hypertension. METHODS We pretreated spontaneously hypertensive rats (SHR… CONTINUE READING