Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription.

@article{Jezova2003AngiotensinIA,
  title={Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription.},
  author={Miroslava Jezova and I Armando and Claudia Bregonzio and Z Yu and Sujuan Qian and V{\'i}ctor J. Ferrans and Hans Imboden and J M Saavedra},
  journal={Endocrinology},
  year={2003},
  volume={144 5},
  pages={2092-101}
}
Angiotensin II (Ang II) AT(1) receptors have been proposed to mediate the Ang II-dependent and the stress-stimulated adrenomedullary catecholamine synthesis and release. However, in this tissue, most of the Ang II receptors are of the AT(2) type. We asked the question whether AT(1) and AT(2) receptors regulate basal catecholamine synthesis. Long-term AT(1) receptor blockade decreased adrenomedullary AT(1) receptor binding, AT(2) receptor binding and AT(2) receptor protein, rat tyrosine… CONTINUE READING

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Increased AT1 receptors in adrenal gland of AT2 receptor gene-disrupted mice

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