• Corpus ID: 23756548

Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells.

@article{Chiu1991AngiotensinIR,
  title={Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells.},
  author={Andrew T. Chiu and William Roscoe and Dale E. McCall and Pieter B.M.W.M. Timmermans},
  journal={Receptor},
  year={1991},
  volume={1 3},
  pages={
          133-40
        }
}
The receptor subtypes that mediate the vasoconstrictor and hypertrophic responses of AII were evaluated in cultured aortic smooth muscle cells from rat. The AII receptors were characterized by means of the subtype-specific receptor antagonists DuP 753 (AII-1) and PD123177 (AII-2) using changes of [Ca2+]i (fura-2) as an indirect measurement of vasoconstriction and of [3H]leucine or [3H]thymidine incorporation as indices for hypertrophy and hyperplasia, respectively. AII-induced [Ca2+]i… 
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BAY 10-6734 appears as a potent and specific new inhibitor of AII-induced growth-related events in VSMCs.
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Recent advances in understanding of Ang II-mediated SMC growth with respect to the role of individual angiotensin receptor subtypes and their associated signaling systems are summarized.
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