Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy.

@article{Mller2000AngiotensinI,
  title={Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy.},
  author={Daniela M{\"u}ller and Eero M. A. Mervaala and Ralf Dechend and Anette Fiebeler and J. K. Park and Folke Schmidt and Juergen Theuer and Volker Breu and Nigel Mackman and Thomas Luther and Wolfgang Schneider and Dietrich C. Gulba and Detlev Ganten and Hermann Haller and Friedrich C. Luft},
  journal={The American journal of pathology},
  year={2000},
  volume={157 1},
  pages={111-22}
}
Tissue factor (TF), a main initiator of clotting, is up-regulated in vasculopathy. We tested the hypothesis that chronic in vivo angiotensin (ANG) II receptor AT(1) receptor blockade inhibits TF expression in a model of ANG II-induced cardiac vasculopathy. Furthermore, we explored the mechanisms by examining transcription factor activation and analyzing the TF promoter. Untreated transgenic rats overexpressing the human renin and angiotensinogen genes (dTGR) feature hypertension and severe left… CONTINUE READING