Angiotensin II, NADPH oxidase, and redox signaling in the vasculature.

  title={Angiotensin II, NADPH oxidase, and redox signaling in the vasculature.},
  author={Aur{\'e}lie Nguyen Dinh Cat and Augusto C. I. Montezano and Dylan Burger and Rhian M Touyz},
  journal={Antioxidants & redox signaling},
  volume={19 10},
SIGNIFICANCE Angiotensin II (Ang II) influences the function of many cell types and regulates many organ systems, in large part through redox-sensitive processes. In the vascular system, Ang II is a potent vasoconstrictor and also promotes inflammation, hypertrophy, and fibrosis, which are important in vascular damage and remodeling in cardiovascular diseases. The diverse actions of Ang II are mediated via Ang II type 1 and Ang II type 2 receptors, which couple to various signaling molecules… CONTINUE READING
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