Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats.

@article{Sato2002AngiotensinIE,
  title={Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats.},
  author={Minoru Sato and Takao Hosokawa and Toshiyasu Yamaguchi and Toshiki Nakano and Koji Muramoto and Takashi Kahara and Katsura Funayama and Akio Kobayashi and Takahisa Nakano},
  journal={Journal of agricultural and food chemistry},
  year={2002},
  volume={50 21},
  pages={6245-52}
}
Seven kinds of angiotensin I-converting enzyme (ACE) inhibitory peptides were isolated from the hydrolysates of wakame (Undaria pinnatifida) by Protease S "Amano" (from Bacillus stearothermophilus) by using three-step high-performance liquid chromatography (HPLC) on a reverse-phase column. These peptides were identified by amino acid composition analysis, sequence analysis, and liquid chromatography-mass spectrometry (LC-MS), as Val-Tyr (IC(50) = 35.2 microM), Ile-Tyr (6.1 microM), Ala-Trp (18… CONTINUE READING

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