Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension.

@article{Hiraga1996AngiotensinIE,
  title={Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension.},
  author={Hiroyuki Hiraga and Tetsuya Oshima and Masazumi Watanabe and Mari Ishida and Takafumi Ishida and Tetsuji Shingu and Masayuki Kambe and Hideo Matsuura and Goro Kajiyama},
  journal={Hypertension},
  year={1996},
  volume={27 3 Pt 2},
  pages={569-72}
}
We undertook the present study in 66 Japanese patients with essential hypertension to identify genetic factors associated with salt sensitivity. Patients were classified into salt-sensitive or salt-resistant groups on the basis of changes in their mean blood pressures from a week of a low salt diet (50 mmol/d) to a week of a high salt diet (340 mmol/d). Salt sensitivity and resistance were studied in relation to a 287-bp insertion/deletion (I/D) polymorphism of the angiotensin I-converting… CONTINUE READING