Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Contributes to Ischemic Stroke Risk: A Meta-Analysis of 50 Case-Control Studies

@article{Zhang2012AngiotensinConvertingEI,
  title={Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Contributes to Ischemic Stroke Risk: A Meta-Analysis of 50 Case-Control Studies},
  author={Zhizhong Zhang and Gelin Xu and Dezhi Liu and Xin-ying Fan and Wusheng Zhu and Xinfeng Liu},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
Background Many studies have investigated the association between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and risk of ischemic stroke. However, the evidence is inadequate to draw robust conclusions because most studies were generally small and conducted in heterogeneous populations. To shed light on these inconclusive findings, we conducted a large meta-analysis of studies relating the ACE I/D polymorphism to the risk of ischemic stroke. Methods… Expand
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TLDR
It is suggested that ACE I/D polymorphisms are associated with ICH, especially in Asians, in a meta-analysis based on the evidence currently available from the literature. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The frequency of the deletion allele D and the polymorphism DD within the gene encoding angiotensin 1-converting enzyme in stroke patients compared with controls was studied to determine if this deletion polymorphism was a potential independent risk factor for stroke. Expand
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