Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for the Prevention of Migraines

@article{Gales2010AngiotensinConvertingEI,
  title={Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for the Prevention of Migraines},
  author={Barry J. Gales and Emilee K Bailey and Ashley N Reed and Mark A. Gales},
  journal={Annals of Pharmacotherapy},
  year={2010},
  volume={44},
  pages={360 - 366}
}
Objective: To evaluate the literature examining the efficacy of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) for migraine prophylaxis. Data Sources: MEDLINE (1966–October 2009) and International Pharmaceutical Abstracts were searched using the terms migraine, headache, renina-ngiotensin system, angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, aldosterone antagonist, and the individual agents in these classes. Study Selection and… Expand
ACE and ARB Agents in the Prophylactic Therapy of Migraine—How Effective Are They?
TLDR
Based upon biologic plausibility, the quality of evidence for efficacy from clinical trials, and recommendations in published guidelines, ACE inhibitors and ARBs are considered as second- or third-line options for migraine prophylaxis. Expand
Inhibitory control of angiotensin-converting enzyme by ramipril in migraine
TLDR
Ramipril prevented migraine attacks independently from blood pressure, and this result supports a link between renin-angiotensin system and migraine pathophysiology. Expand
Transdermal delivery of angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEIs) and others for management of hypertension
TLDR
Transdermal delivery of different ARBs and ACEIs improves bioavailability as well as patient compliance by many folds and the rationale development of some newer ARBs, ACEIs and other anti-hypertensives transdermal systems will provide new ways of treatment, circumventing current limitations for conventional dosage forms. Expand
Renin–angiotensin system in pain: Existing in a double life?
TLDR
The dual role of the RAAS in different states of pain is described, including the pain-relieving actions of angiotensin II (AngII) and pain-inducing actions of AT1 blockers. Expand
Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis
TLDR
The data suggest that the ACE II genotype could exert a protective effect against migraine with aura and without aura at least in the Turkish population. Expand
ROLE OF ACE INHIBITORS & AT-II RECEPTOR ANTAGONISTS IN MIGRAINE PROPHYLAXIS : AN OVERVIEW
TLDR
A new class of drugs like angiotensin-converting enzyme inhibitors (ACE inhibitors) and ang Elliotensin II receptor antagonists have recently been studied for their off label use in prophylaxis of migraine, with results in favour of their clinical use because of the ability to reduce number of days with headache. Expand
Preoperative Angiotensin-converting Enzyme Inhibitor Use is Not Associated With Increased Postoperative Pain and Opioid Use
TLDR
No significant difference was found that postoperative pain—as defined by either pain scores or opioid requirements—differed between patients taking ACEIs and patients not takingACEIs. Expand
Inhibition of Angiotensin Converting Enzyme, Angiotensin II Receptor Blocking, and Blood Pressure Lowering Bioactivity across Plant Families
TLDR
In vitro and in vivo reports of plant-derived extracts that inhibit ACE activity, block angiotensin II receptor binding and demonstrate hypotensive activity in animal or human studies are reviewed. Expand
The effectiveness of aspirin for migraine prophylaxis: a systematic review.
TLDR
Aspirin can reduce the frequency of migraines, however, the optimal dosage is unclear and the risk of bias was generally low or unclear. Expand
Real world effectiveness and tolerability of candesartan in the treatment of migraine: a retrospective cohort study
TLDR
C candesartan showed beneficial effects in the preventive treatment of migraine in clinical practice, including patients with chronic migraine, medication-overuse headache and resistance to prior prophylactics. Expand
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References

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Efficacy of angiotensin II receptor antagonists in preventing headache: a systematic overview and meta-analysis.
TLDR
Angiotensin II receptor antagonists appear to be effective in preventing headaches, but the mechanism of this benefit and the types of headaches that are prevented are not known. Expand
Involvement of the renin–angiotensin system in migraine
TLDR
It is likely that the RAS has a clinically important role in migraine pathophysiology, and clinical trials indicated that angiotensin-converting enzyme inhibitors (ACEIs) and angiotENSin II receptor blockers (ARBs) are effective in the prophylactic treatment of migraine. Expand
Losartan and severe migraine.
TLDR
A patient is described who developed a severe classic migrainous headache while receiving losartan therapy, and the manufacturer states that except for a low incidence of dizziness,Losartan has caused no adverse effects at a significantly higher rate than those found with placebo. Expand
Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial.
TLDR
In this study, the angiotensin II receptor blocker candesartan provided effective migraine prophylaxis, with a tolerability profile comparable with that of placebo, with no significant differences in health-related quality of life. Expand
Angiotensin-converting enzyme gene insertion/deletion polymorphism in migraine patients
TLDR
ACE genotype in the experience did not predict the clinical response to lisinopril or candesartan used as migraine prophylactics and there was no association between ACE genotype or allele frequency and migraine. Expand
Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomised, placebo controlled, crossover study
TLDR
Analysis of data from 55 patients supported the differences in favour of lisinopril for the primary end points, and concluded that the angiotensin converting enzyme inhibitor, lisinobril, has a clinically important prophylactic effect in migraine. Expand
Reduction in the therapeutic intensity of abortive migraine drug use during ACE inhibition therapy—a pilot study
TLDR
The impact of ACE inhibitors and angiotensin II receptor antagonists on the consumption of specific abortive migraine drugs and, therefore, indirectly on the frequency of migraine attacks is studied. Expand
Association Between ACE Inhibitors Use and Headache Caused by Nitrates Among Hypertensive Patients: Results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA)
TLDR
It is suggested that among hypertensive subjects use of ACE inhibitors is associated with a reduced risk of headache caused by nitrates, and this result was confirmed if ACE inhibitors use was compared with use of other antihypertensive agents. Expand
Telmisartan in Migraine Prophylaxis: A Randomized, Placebo-Controlled Trial
TLDR
It is indicated that telmisartan might be effective in migraine prophylaxis, and a borderline significant difference in responders is seen. Expand
Improvement of Dialysis Headache After Treatment with ACE-Inhibitors but not Angiotensin II Receptor Blocker: A Case Report with Pathophysiological Considerations
TLDR
It is intriguing that nephrectomy or transplantation may prompt a marked improvement in the headache which occurrs during subsequent dialyses, and prompted us to postulate, that the ReninAngiotensin-system may be involved in the pathophysiology of dialysis headache. Expand
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