Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System

@article{Wang2016AngiotensinConvertingE2,
  title={Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System},
  author={W. Wang and Shaun M K McKinnie and Maikel A Farhan and Manish Paul and T. McDonald and Brent A. McLean and C. Llorens-Cortes and S. Hazra and A. Murray and J. Vederas and G. Oudit},
  journal={Hypertension},
  year={2016},
  volume={68},
  pages={365–377}
}
  • W. Wang, Shaun M K McKinnie, +8 authors G. Oudit
  • Published 2016
  • Medicine
  • Hypertension
  • Apelin peptides mediate beneficial effects on the cardiovascular system and are being targeted as potential new drugs. However, apelin peptides have extremely short biological half-lives, and improved understanding of apelin peptide metabolism may lead to the discovery of biologically stable analogues with therapeutic potential. We examined the ability of angiotensin-converting enzyme 2 (ACE2) to cleave and inactivate pyr-apelin 13 and apelin 17, the dominant apelin peptides. Computer-assisted… CONTINUE READING
    65 Citations

    Paper Mentions

    OBSERVATIONAL PATIENT REGISTRY CLINICAL TRIAL
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    ConditionsCovid19
    InterventionDiagnostic Test
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    References

    SHOWING 1-10 OF 45 REFERENCES
    Apelin is a positive regulator of ACE2 in failing hearts.
    • 98
    • PDF
    Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release.
    • 301
    • PDF
    The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism
    • 540
    • Highly Influential
    Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase*
    • 1,016
    • PDF
    Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS.
    • 109
    Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects
    • 147