Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System

  title={Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System},
  author={W. Wang and Shaun M K McKinnie and Maikel A Farhan and Manish Paul and T. McDonald and Brent A. McLean and C. Llorens-Cortes and S. Hazra and A. Murray and J. Vederas and G. Oudit},
  • W. Wang, Shaun M K McKinnie, +8 authors G. Oudit
  • Published 2016
  • Medicine
  • Hypertension
  • Apelin peptides mediate beneficial effects on the cardiovascular system and are being targeted as potential new drugs. However, apelin peptides have extremely short biological half-lives, and improved understanding of apelin peptide metabolism may lead to the discovery of biologically stable analogues with therapeutic potential. We examined the ability of angiotensin-converting enzyme 2 (ACE2) to cleave and inactivate pyr-apelin 13 and apelin 17, the dominant apelin peptides. Computer-assisted… CONTINUE READING
    65 Citations

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