Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System

@article{Wang2016AngiotensinConvertingE2,
  title={Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System},
  author={Wang Wang and Shaun M. K. McKinnie and Maikel A Farhan and Manish Paul and Tyler McDonald and Brent A. McLean and Catherine Llorens-Cortes and Saugata Hazra and Allan G. Murray and John C. Vederas and Gavin Y. Oudit},
  journal={Hypertension},
  year={2016},
  volume={68},
  pages={365–377}
}
Apelin peptides mediate beneficial effects on the cardiovascular system and are being targeted as potential new drugs. However, apelin peptides have extremely short biological half-lives, and improved understanding of apelin peptide metabolism may lead to the discovery of biologically stable analogues with therapeutic potential. We examined the ability of angiotensin-converting enzyme 2 (ACE2) to cleave and inactivate pyr-apelin 13 and apelin 17, the dominant apelin peptides. Computer-assisted… Expand
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