Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt-induced fibrosis.

@article{Robert1999AngiotensinAR,
  title={Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt-induced fibrosis.},
  author={Val{\'e}rie J.P. Robert and Christophe Heymes and J S Silvestre and Alia Sabri and Bernard Swynghedauw and Claude Delcayre},
  journal={Hypertension},
  year={1999},
  volume={33 4},
  pages={981-6}
}
This study tests the hypothesis that aldosterone induces cardiac fibrosis through an increase of cardiac angiotensin II (Ang II) AT1 receptor levels, thereby potentiating the fibrotic effect of Ang II by determining the effects of spironolactone and losartan on cardiac fibrosis, AT1 density, and gene expression in aldosterone-salt-treated rats. Fibrosis was quantified by slot blots of collagen I and III mRNA levels and videomorphometry of Sirius red-stained collagen. AT1 receptor density was… CONTINUE READING

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