Angiotensin AT1 receptor-mediated attenuation of cardiac hypertrophy due to volume overload: involvement of endothelin.

@article{Ishiye1995AngiotensinAR,
  title={Angiotensin AT1 receptor-mediated attenuation of cardiac hypertrophy due to volume overload: involvement of endothelin.},
  author={Masayuki Ishiye and Kazuo Umemura and Toshihiko Uematsu and Mitsuyoshi Nakashima},
  journal={European journal of pharmacology},
  year={1995},
  volume={280 1},
  pages={11-7}
}
The role of angiotensin II via the angiotensin type 1 (AT1) receptor in the development of volume overload cardiac hypertrophy was investigated in adult male Wistar rats with aortic insufficiency. We examined the effects of specific angiotensin AT1 receptor blockade with losartan (2-n-butyl-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]-imidazole potassium) on left ventricular weight and left ventricular angiotensin II and endothelin-1 level to test the possibility that… CONTINUE READING

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