Angiotensin-(1-7) serves as an aquaretic by increasing water intake and diuresis in association with downregulation of aquaporin-1 during pregnancy in rats.

@article{Joyner2008Angiotensin17SA,
  title={Angiotensin-(1-7) serves as an aquaretic by increasing water intake and diuresis in association with downregulation of aquaporin-1 during pregnancy in rats.},
  author={Janae Joyner and Liomar A. A. Neves and Kathryn Stovall and Carlos Maria Ferrario and K. Bridget Brosnihan},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 3},
  pages={R1073-80}
}
We previously demonstrated that kidney and urine levels of angiotensin-(1-7) [ANG-(1-7)] were increased in pregnancy. To explore the role of ANG-(1-7) on fluid and electrolyte homeostasis during pregnancy, we evaluated the effect of the ANG-(1-7) antagonist D-alanine-[ANG-(1-7)] (A-779) on kidney function. Virgin and pregnant rats received infusion of vehicle or A-779 (48 microg.kg(-1).h(-1)) for 8 days by osmotic minipumps. Metabolic studies were done on treatment day 7-8. Virgin and pregnant… CONTINUE READING

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