Angiotensin-(1-7) receptor Mas agonist ameliorates progress of atherosclerosis in apoE-knockout mice.

@article{Jawie2012Angiotensin17RM,
  title={Angiotensin-(1-7) receptor Mas agonist ameliorates progress of atherosclerosis in apoE-knockout mice.},
  author={Jacek Jawień and Justyna Totoń-Żurańska and Mariusz Gajda and Anna Niepsuj and Anna Gębska and Katarzyna Kuś and Maciej Suski and Grażyna Pyka-Fościak and Bernadeta Nowak and Tomasz J. Guzik and Jadwiga Marcinkiewicz and Rafał Olszanecki and Ryszard Korbut},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2012},
  volume={63 1},
  pages={77-85}
}
Our interest focused on an open question whether AT-(1-7), nonpeptide receptor agonist: AVE 0991, is able to ameliorate atherosclerosis. We used an apolipoprotein E (apoE) - knockout mice model of atherosclerosis. Experimental groups received the same diet as control, mixed with: AVE 0991 at a dose of 0.58 μmol/kg b.w./day, perindopril at a dose of 0.4 mg/kg b.w./day or with tiorphan at a dose of 2.5 mg/kg b.w./day. A-779 [(D-alanine)-angiotensin (1-7)] was given at a dose of 3.3 mg/kg b.w., 3… CONTINUE READING
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