Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension.

@article{Nakamoto1995Angiotensin17AN,
  title={Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension.},
  author={Hidetomo Nakamoto and Carlos Maria Ferrario and Sawyer B. Fuller and D L Robaczewski and E Winicov and R. H. Dean},
  journal={Hypertension},
  year={1995},
  volume={25 4 Pt 2},
  pages={796-802}
}
New studies suggest that vasodilator systems may play an important role in restraining the rise in peripheral vascular resistance associated with the evolution of arterial hypertension. We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega-nitro-L-arginine (3 mg.kg-1.d-1) or the nitric oxide precursor L-arginine (0.3 mg.kg-1.d-1) during the evolution of two-kidney, one clip hypertension. Inhibition of… CONTINUE READING

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We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega - nitro - L - arginine ( 3 mg.kg-1.d-1 ) or the nitric oxide precursor L - arginine ( 0.3 mg.kg-1.d-1 ) during the evolution of two - kidney , one clip hypertension .
We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega - nitro - L - arginine ( 3 mg.kg-1.d-1 ) or the nitric oxide precursor L - arginine ( 0.3 mg.kg-1.d-1 ) during the evolution of two - kidney , one clip hypertension .
We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega - nitro - L - arginine ( 3 mg.kg-1.d-1 ) or the nitric oxide precursor L - arginine ( 0.3 mg.kg-1.d-1 ) during the evolution of two - kidney , one clip hypertension .
We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega - nitro - L - arginine ( 3 mg.kg-1.d-1 ) or the nitric oxide precursor L - arginine ( 0.3 mg.kg-1.d-1 ) during the evolution of two - kidney , one clip hypertension .
In contrast , chronic administration of L - arginine had no effect on the magnitude of hypertension or on the increases in renin activity and hyperangiotensinemia associated with the evolution of renal hypertension .
During the chronic phase of renovascular hypertension , the fall in blood pressure produced by acute systemic injections of lisinopril or losartan was significantly reduced in dogs given the nitric oxide inhibitor .
During the chronic phase of renovascular hypertension , the fall in blood pressure produced by acute systemic injections of lisinopril or losartan was significantly reduced in dogs given the nitric oxide inhibitor .
In contrast , chronic administration of L - arginine had no effect on the magnitude of hypertension or on the increases in renin activity and hyperangiotensinemia associated with the evolution of renal hypertension .
In contrast , chronic administration of L - arginine had no effect on the magnitude of hypertension or on the increases in renin activity and hyperangiotensinemia associated with the evolution of renal hypertension .
The vasodilator component of the blood pressure response due to intravenous injections of angiotensin-(1 - 7 ) ( 1 to 100 nmol / kg ) was augmented in both untreated and L - arginine - treated two - kidney , one clip hypertensive dogs , but was significantly attenuated in hypertensive dogs fed the nitric oxide synthase inhibitor.(ABSTRACT TRUNCATED AT 250 WORDS ) .
During the chronic phase of renovascular hypertension , the fall in blood pressure produced by acute systemic injections of lisinopril or losartan was significantly reduced in dogs given the nitric oxide inhibitor .
During the chronic phase of renovascular hypertension , the fall in blood pressure produced by acute systemic injections of lisinopril or losartan was significantly reduced in dogs given the nitric oxide inhibitor .
We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega - nitro - L - arginine ( 3 mg.kg-1.d-1 ) or the nitric oxide precursor L - arginine ( 0.3 mg.kg-1.d-1 ) during the evolution of two - kidney , one clip hypertension .
We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega - nitro - L - arginine ( 3 mg.kg-1.d-1 ) or the nitric oxide precursor L - arginine ( 0.3 mg.kg-1.d-1 ) during the evolution of two - kidney , one clip hypertension .
We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega - nitro - L - arginine ( 3 mg.kg-1.d-1 ) or the nitric oxide precursor L - arginine ( 0.3 mg.kg-1.d-1 ) during the evolution of two - kidney , one clip hypertension .
We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega - nitro - L - arginine ( 3 mg.kg-1.d-1 ) or the nitric oxide precursor L - arginine ( 0.3 mg.kg-1.d-1 ) during the evolution of two - kidney , one clip hypertension .
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