Angiotensin-(1-7): beyond the cardio-renal actions.

  title={Angiotensin-(1-7): beyond the cardio-renal actions.},
  author={Danielle Gomes Passos-Silva and Thiago Verano-Braga and Robson Augusto Souza Santos},
  journal={Clinical science},
  volume={124 7},
It is well known that the RAS (renin-angiotensin system) plays a key role in the modulation of many functions in the body. AngII (angiotensin II) acting on AT1R (type 1 AngII receptor) has a central role in mediating most of the actions of the RAS. However, over the past 10 years, several studies have presented evidence for the existence of a new arm of the RAS, namely the ACE (angiotensin-converting enzyme) 2/Ang-(1-7) [angiotensin-(1-7)]/Mas axis. Ang-(1-7) can be produced from AngI or AngII… 

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The demonstration that Ang-(1–7) is a key component of the RAS represented one of the most significant conceptual changes of this important hormonal system and the potential of Ang-1-7 and other Mas agonists as cardiometabolic therapeutic agents is focused on.

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  • 2005
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The role of the ACE2/ANG-(1-7)/Mas receptor is summarized, focusing on the central nervous system with respect to cardiovascular diseases such as hypertension, chronic heart failure, and stroke, as well as neurological diseases.

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