Angiotensin-(1--7) in the ovine fetus.

@article{Moritz2001Angiotensin17IT,
  title={Angiotensin-(1--7) in the ovine fetus.},
  author={Karen M. Moritz and Duncan J Campbell and E. Marelyn Wintour},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2001},
  volume={280 2},
  pages={
          R404-9
        }
}
  • K. Moritz, D. Campbell, E. Wintour
  • Published 1 February 2001
  • Medicine, Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
In the adult animal, ANG-(1-7) may counterbalance some effects of ANG II. Its effects in the fetus are unknown. Basal ANG-(1-7), ANG I, ANG II, and renin concentrations were measured in plasma from ovine fetuses and their mothers (n = 10) at 111 days of gestation. In the fetus, concentrations of ANG I, ANG-(1-7), and ANG II were 86 +/- 21, 13 +/- 2, and 14 +/- 2 fmol/ml, respectively. In the ewe, concentrations of ANG I were significantly lower (20 +/- 4 fmol/ml, P < 0.05) as were… 
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18 Citations
Background Citations
6
Methods Citations
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18 Citations

Citation Type

Citation Type

Administration of D-Alanine-[Ang-(1-7)] (A-779) Prior to Pregnancy in Sprague Dawley Rats Produces Antidiuresis in Late Gestation.
Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats.
TLDR
It is shown for the first time that ANG-(1-7) has a previously unsuspected potent effect in the blood flow distribution and systemic hemodynamics and the effects of A-779 on the cerebral blood flow, cardiac index, systolic volume, and total peripheral resistance were partially attenuated.
Maternal glucocorticoid treatment programs alterations in the renin-angiotensin system of the ovine fetal kidney.
TLDR
The results indicate that treatment with D very early in gestation causes significant alterations in the RAS in the fetal kidney 100 d later with functional consequences, which may be an important mechanism in the development of adult disease.
Angiotensin II receptor (type 1 and 2) expression peaks when placental growth is maximal in sheep.
TLDR
Results suggest that ANG II, via the AT(1) receptor, may have hitherto unsuspected important roles in the growth/function on the ovine placenta during the maximal growth phase.
Phosphoinositide hydrolysis increase by angiotensin-(1–7) in neonatal rat brain
Role of the vasodilator peptide angiotensin-(1–7) in cardiovascular drug therapy
TLDR
Data now demonstrate that Ang-(1–7) contributes to the cardiovascular effects of ACE-inhibitors (ACE-I) and AT1-receptor-blockers (ARBs) both in experimental conditions and in humans.
The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos
TLDR
Ex vivo experiments showed in an in vivo animal model that endogenous expression levels of ACE2 and the Mas receptor were upregulated in mouse pancreata in late embryogenesis, suggesting that a Mas receptor-mediated mechanism may stimulate pancreatic cell development.
Selective down-regulation of AT2 receptors in uterine arteries from pregnant ewes given 24-h intravenous infusions of angiotensin II
Infusion of angiotensin-(1-7) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritis.
TLDR
In vitro data indicate that ANG II-induced increases in mesangial cell proliferation and plasminogen activator inhibitor-1 overexpression are inhibited by ANG-(1-7) via its binding to a specific receptor known as Mas.
Interactions between angiotensin-(1-7), kinins, and angiotensin II in kidney and blood vessels.
TLDR
Novel aspects of the biological actions of Ang-(1-7), dealing with its interaction with Ang II and kinins, especially in the kidney and blood vessels are reviewed.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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