Angiotensin-(1–7)/Mas axis integrity is required for the expression of object recognition memory

  title={Angiotensin-(1–7)/Mas axis integrity is required for the expression of object recognition memory},
  author={Thiago L.N. Lazaroni and Ana Cl{\'a}udia S. Raslan and Walkiria R.P. Fontes and Marilene L. de Oliveira and Michael Bader and Natalia Alenina and M{\'a}rcio F. D. Moraes and Robson Augusto Souza Santos and Grace Schenatto Pereira},
  journal={Neurobiology of Learning and Memory},
It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Interestingly, hippocampus is one of the regions with higher expression of Mas. However, the role of Ang-(1-7)/Mas axis in hippocampus-dependent memories is still poorly understood. Here… CONTINUE READING


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