Angiotensin‐converting enzyme 2 deficiency accelerates and angiotensin 1‐7 restores age‐related muscle weakness in mice

@inproceedings{Takeshita2018AngiotensinconvertingE2,
  title={Angiotensin‐converting enzyme 2 deficiency accelerates and angiotensin 1‐7 restores age‐related muscle weakness in mice},
  author={Hikari Takeshita and Koichi Yamamoto and Satoko Nozato and Masao Takeda and So‐ichiro Fukada and Tadakatsu Inagaki and Hirotsugu Tsuchimochi and Mikiyasu Shirai and Yoichi Nozato and Taku Fujimoto and Yuki Imaizumi and Serina Yokoyama and Motonori Nagasawa and Go Hamano and Kazuhiro Hongyo and T Kawai and Hiroko Hanasaki‐Yamamoto and Shuko Takeda and Toshimasa Takahashi and Hiroshi Akasaka and Norihisa Itoh and Yoichi Takami and Yasushi Takeya and Ken Sugimoto and Hironori Nakagami and Hiromi Rakugi},
  booktitle={Journal of cachexia, sarcopenia and muscle},
  year={2018}
}
BACKGROUND A pharmacologic strategy for age-related muscle weakness is desired to improve mortality and disability in the elderly. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II into angiotensin 1-7, a peptide known to protect against acute and chronic skeletal muscle injury in rodents. Since physiological aging induces muscle weakness via mechanisms distinct from other muscle disorders, the role of ACE2-angiotensin 1-7 in age-related muscle weakness remains undetermined. Here… CONTINUE READING
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