Angiotensin‐Converting Enzyme Inhibitory Activity of SCH 31846, a New Non‐Sulfhydryl Inhibitor

  title={Angiotensin‐Converting Enzyme Inhibitory Activity of SCH 31846, a New Non‐Sulfhydryl Inhibitor},
  author={E. Sybertz and T. Baum and H. S. Ahn and S. Nelson and E. Eynon and D. Desiderio and K. Pula and F. Becker and C. Sabin and R. Moran and G. V. Vliet and B. Kastner and E. Smith},
  journal={Journal of Cardiovascular Pharmacology},
  • E. Sybertz, T. Baum, +10 authors E. Smith
  • Published 1983
  • Medicine
  • Journal of Cardiovascular Pharmacology
  • Summary SCH 31846, 1-(N-[1(5)-(ethoxycarbonyl)-3-phenylpropyl] - (S)-alanyl) - cis, syn-octahydro - (H-indole-2-S)-carboxylic acid; CI-907; PD 109, 763–2, is a new non-sulfhydryl-containing, angiotensin-converting enzyme (ACE) inhibitor. The present investigation describes its ACE inhibitory properties and compares them to those of MK 421. The diacid of SCH 31846 inhibited rabbit pulmonary ACE with an IC50 of 2.2 nM (MK 421 diacid 2.5 nM). The drug behaved as a competitive and specific… CONTINUE READING
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