Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment.

  title={Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment.},
  author={Triantafyllos Chavakis and By Athanasios Athanasopoulos and J Rhee and Valeria V Orlova and Thomas Schmidt-W{\"o}ll and Angelika Bierhaus and Andreas Eberhard May and Ilhan Celik and Peter P Nawroth and Klaus Theo Preissner},
  volume={105 3},
Angiogenesis and inflammation are closely related biologic processes in wound healing and the responses to vascular injury as well as in cardiovascular diseases; however, the molecular connections are poorly defined. In particular, it is yet unclear whether endogenous factors can regulate both angiogenesis and inflammation. Here, we show that the endogenous angiogenesis inhibitor, angiostatin (containing kringle domains 1-4 of plasminogen), serves an anti-inflammatory role, since the kringles 1… CONTINUE READING


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