Angiostatin inhibits activation and migration of neutrophils

  title={Angiostatin inhibits activation and migration of neutrophils},
  author={Gurpreet Kaur Aulakh and Yadu Balachandran and Long Liu and Baljit Singh},
  journal={Cell and Tissue Research},
There is a critical need to identify molecules that modulate the biology of neutrophils because activated neutrophils, though necessary for host defense, cause exuberant tissue damage through production of reactive oxygen species and increased lifespan. Angiostatin, an endogenous anti-angiogenic cleavage product of plasminogen, binds to integrin αvβ3, ATP synthase and angiomotin and its expression is increased in inflammatory conditions. We test the hypothesis that angiostatin inhibits… CONTINUE READING