Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

@article{Oreilly1994AngiostatinAN,
  title={Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma},
  author={Michael S O'reilly and Lars Holmgren and Yuen W. Shing and C-F. Chen and Randy Rosenthal and Marsha A. Moses and William S. Lane and Yihai Cao and Elizabeth Sage and Judah M Folkman},
  journal={Cell},
  year={1994},
  volume={79},
  pages={315-328}
}
The phenomenon of inhibition of tumor growth by tumor mass has been repeatedly studied, but without elucidation of a satisfactory mechanism. In our animal model, a primary tumor inhibits its remote metastases. After tumor removal, metastases neovascularize and grow. When the primary tumor is present, metastatic growth is suppressed by a circulating angiogenesis inhibitor. Serum and urine from tumor-bearing mice, but not from controls, specifically inhibit endothelial cell proliferation. The… CONTINUE READING
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