Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses.

Abstract

Angiopoietin-1 (Ang1) and -2 (Ang2) are endothelial growth factors that bind to the tyrosine kinase receptor Tie2 and contribute to orchestrate blood vessel formation during angiogenesis. Ang1 mediates vessel maturation and integrity by the recruitment of pericytes. In contrast, Ang2 is classically considered as a Tie2 antagonist, counteracting the… (More)

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Cite this paper

@article{Lemieux2005AngiopoietinsCD, title={Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses.}, author={Caroline Lemieux and Ricardo Maliba and Judith Favier and J. J. Theoret and Yahye Merhi and Martin G. Sirois}, journal={Blood}, year={2005}, volume={105 4}, pages={1523-30} }