Angiopoietins and angiopoietin-like proteins in angiogenesis.

  title={Angiopoietins and angiopoietin-like proteins in angiogenesis.},
  author={Tohru Morisada and Yoshiaki Kubota and Takashi Urano and Toshio Suda and Yuichi Oike},
  journal={Endothelium : journal of endothelial cell research},
  volume={13 2},
Vascular network formation requires several endothelial cell growth factors. These factors have a potent angiogenic effect, and their precise coordination is essential for vascular development. Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling. It has been reported that the angiopoietin/Tie2 signal is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance… CONTINUE READING