Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor.

@article{Iivanainen2003AngiopoietinregulatedRO,
  title={Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor.},
  author={Erika Iivanainen and Lassi Nelimarkka and Varpu Elenius and Satu-Maria Heikkinen and Teemu T. Junttila and Laura Sihombing and Maria Sundvall and Jorma A Maatta and Veli Jukka O Laine and Seppo Yla-Herttuala and Shigeki Higashiyama and Kari Alitalo and Klaus Elenius},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 12},
  pages={1609-21}
}
Recruitment of vascular smooth muscle cells (SMC) by endothelial cells (EC) is essential for angiogenesis. Endothelial-derived heparin binding EGF-like growth factor (HB-EGF) was shown to mediate this process by signaling via ErbB1 and ErbB2 receptors in SMCs. 1) Analysis of ErbB-ligands demonstrated that primary ECs expressed only HB-EGF and neuregulin-1. 2) Primary SMCs expressed ErbB1 and ErbB2, but not ErbB3 or ErbB4. 3) Consistent with their known receptor specificities, recombinant HB-EGF… CONTINUE READING

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