Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility.

  title={Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility.},
  author={Tsang-Chih Kuo and Ching-Ting Tan and Yi-Wen Chang and C Hong and Wei-Jiunn Lee and Min-Wei Chen and Yung-Ming Jeng and Jean Chiou and Pei Yu and Pai-Sheng Chen and Ming-yang Wang and Michael Hsiao and J Su and M -L Kuo},
  journal={The Journal of clinical investigation},
  volume={123 3},
Angiopoietin-like protein 1 (ANGPTL1) is a potent regulator of angiogenesis. Growing evidence suggests that ANGPTL family proteins not only target endothelial cells but also affect tumor cell behavior. In a screen of 102 patients with lung cancer, we found that ANGPTL1 expression was inversely correlated with invasion, lymph node metastasis, and poor clinical outcomes. ANGPTL1 suppressed the migratory, invasive, and metastatic capabilities of lung and breast cancer cell lines in vitro and… CONTINUE READING