Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor.

@article{Kuchtey2008Angiopoietinlike7S,
  title={Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor.},
  author={John G Kuchtey and Maria E K{\"a}llberg and Kirk N. Gelatt and Tommy A. Rinkoski and Andr{\'a}s M Kom{\'a}romy and Rachel W. Kuchtey},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 8},
  pages={3438-48}
}
PURPOSE To investigate the possibility that Angiopoietin-like 7 (ANGPTL7) protein is involved in the pathogenesis of glaucoma. METHODS Primary human trabecular meshwork (TM) cells and corneoscleral explants were stimulated with either dexamethasone (DEX) or transforming growth factor beta (TGFbeta), and ANGPTL7 protein secreted into culture medium was determined by Western blot analysis. The effect of stable overexpression of ANGPTL7 in transfected immortalized TM cell lines on collagen… CONTINUE READING
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