Angiopoietin-Like Protein 2 Acts as a Novel Biomarker for Diagnosis and Prognosis in Patients with Esophageal Cancer

@article{Ide2014AngiopoietinLikeP2,
  title={Angiopoietin-Like Protein 2 Acts as a Novel Biomarker for Diagnosis and Prognosis in Patients with Esophageal Cancer},
  author={Shozo Ide and MD Yuji Toiyama and MD Tadanobu Shimura and MD Mikio Kawamura and MD Hiromi Yasuda and MD Susumu Saigusa and MD Masaki Ohi and MD Koji Tanaka and MD Yasuhiko Mohri and MD Masato Kusunoki},
  journal={Annals of Surgical Oncology},
  year={2014},
  volume={22},
  pages={2585-2592}
}
Angiopoietin-like protein 2 (ANGPTL2) mediates chronic inflammation. Tumor cell-derived ANGPTL2 promotes tumor invasion and angiogenesis. Overexpression of ANGPTL2 in tumor cells is associated with tumor progression and has been recognized in lung, breast, colon, and gastric cancer. However, to our knowledge the functional and clinical significance of ANGPTL2 expression has not been investigated in patients with esophageal cancer (EC). First, in vitro assays were performed for functional… CONTINUE READING