Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis.

@article{Krausz2012Angiopoietin2PI,
  title={Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis.},
  author={Sarah Krausz and Samuel Garc{\'i}a and Carmen A. Ambarus and Daphne de Launay and Martyn Foster and Brian Naiman and William O. Iverson and Jane R Connor and Matthew A Sleeman and Anthony J Coyle and Jorg Hamann and D. Baeten and Paul Peter Tak and Kris A. Reedquist},
  journal={Annals of the rheumatic diseases},
  year={2012},
  volume={71 8},
  pages={1402-10}
}
BACKGROUND Angiopoietin (Ang)-1 and Ang-2, and their shared receptor Tie2, are expressed in rheumatoid arthritis (RA) synovial tissue, but the cellular targets of Ang signalling and the relative contributions of Ang-1 and Ang-2 to arthritis are poorly understood. OBJECTIVES To determine the cellular targets of Ang signalling in RA synovial tissue, and the effects of Ang-2 neutralisation in murine collagen-induced arthritis (CIA). METHODS RA and psoriatic arthritis (PsA) synovial biopsies… CONTINUE READING

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