Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma.

  title={Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma.},
  author={Iris Helfrich and L. Edler and Antje Sucker and Markus Thomas and Sven Christian and Dirk Schadendorf and Hellmut G Augustin},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={15 4},
PURPOSE The blood vessel-destabilizing Tie2 ligand angiopoietin-2 (Ang-2) acts in concert with the vascular endothelial growth factor/vascular endothelial growth factor receptor system to control vessel assembly during tumor progression. We hypothesized that circulating soluble Ang-2 (sAng-2) may be involved in melanoma progression. EXPERIMENTAL DESIGN Serum samples (n=98) from melanoma patients (American Joint Committee on Cancer stages I-IV), biopsies of corresponding patients, and human… CONTINUE READING


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