Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

@article{Gale2002Angiopoietin2IR,
  title={Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.},
  author={Nicholas Gale and Gavin Thurston and Sean Francis Hackett and Roumiana Renard and Quan Wang and Joyce McClain and Cliff Martin and Charles L. Witte and Marlys Hearst Witte and David Y Jackson and Chitra Suri and Peter Anthony Campochiaro and Stanley J. Wiegand and George D. Yancopoulos},
  journal={Developmental cell},
  year={2002},
  volume={3 3},
  pages={411-23}
}
VEGF and Angiopoietin-1 requisitely collaborate during blood vessel development. While Angiopoietin-1 obligately activates its Tie2 receptor, Angiopoietin-2 can activate Tie2 on some cells, while it blocks Tie2 activation on others. Our analysis of mice lacking Angiopoietin-2 reveals that Angiopoietin-2 is dispensable for embryonic vascular development but is requisite for subsequent angiogenic remodeling. Unexpectedly, mice lacking Angiopoietin-2 also exhibit major lymphatic vessel defects… CONTINUE READING
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