Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.

  title={Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.},
  author={Bo Hu and Ping Guo and Quan Fang and H Tao and De-gui Wang and Motoo Nagane and H S Huang and Yuji Gunji and Ryo Nishikawa and Kari Alitalo and Webster K Cavenee and Shi-Yuan Cheng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 15},
A hallmark of highly malignant human gliomas is their infiltration of the brain. We analyzed a large number of primary human glioma biopsies and found high levels of expression of an angiogenic regulator, angiopoietin-2 (Ang2), in the invasive areas, but not in the central regions, of those tumors. In the invasive regions where Ang2 was overexpressed, increased levels of matrix metalloprotease-2 (MMP-2) were also apparent. Consonant with these features, intracranial xenografts of glioma cells… CONTINUE READING

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