Angiopoietin-2 Is a Direct Transcriptional Target of TAL1, LYL1 and LMO2 in Endothelial Cells

  title={Angiopoietin-2 Is a Direct Transcriptional Target of TAL1, LYL1 and LMO2 in Endothelial Cells},
  author={Virginie Deleuze and Rawan El-Hajj and Elias Chalhoub and Christiane Dohet and Val{\'e}rie Pinet and Philippe Couttet and Dani{\`e}le Mathieu},
  booktitle={PloS one},
The two related basic helix-loop-helix, TAL1 and LYL1, and their cofactor LIM-only-2 protein (LMO2) are present in blood and endothelial cells. While their crucial role in early hematopoiesis is well established, their function in endothelial cells and especially in angiogenesis is less understood. Here, we identified ANGIOPOIETIN-2 (ANG-2), which encodes a major regulator of angiogenesis, as a direct transcriptional target of TAL1, LYL1 and LMO2. Knockdown of any of the three transcription… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations

Lung endothelial barrier disruption in Lyl1-deficient mice.

American journal of physiology. Lung cellular and molecular physiology • 2014
View 3 Excerpts


Publications referenced by this paper.
Showing 1-10 of 58 references

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex

K El Omari, SJ Hoosdally, K Tuladhar, D Karia, P Vyas
Blood • 2011
View 7 Excerpts
Highly Influenced

HMEC-1: establishment of an immortalized human microvascular endothelial cell line.

The Journal of investigative dermatology • 1992
View 7 Excerpts
Highly Influenced

SCL: from the origin of hematopoiesis to stem cells and leukemia.

Experimental hematology • 2004
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…