Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense.

@article{David2011Angiopoietin1RI,
  title={Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense.},
  author={Sascha A David and Chandra C. Ghosh and Aditi Mukherjee and Samir M Parikh},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 11},
  pages={2643-52}
}
OBJECTIVE IQ domain GTPase-activating protein 1 (IQGAP1) contributes to cytoskeletal network regulation in epithelial cells by its scaffolding properties and by binding the Rho GTPase Rac1 to maintain its activity. The functions of IQGAP1 in endothelial cells beyond angiogenesis remain unclear. We hypothesized that IQGAP1 participates in the regulation of endothelial barrier function. METHODS AND RESULTS Silencing IQGAP1 in human microvascular endothelial cells resulted in a disruption of… CONTINUE READING