Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells.

@article{Ismail2010Angiopoietin1RH,
  title={Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells.},
  author={Nesreen S. Ismail and Elke A Pravda and Dan Li and Shou-Ching Shih and Susan M. Dallabrida},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 5},
  pages={1307-17}
}
UV light-based damage to skin cells can cause photoaging and skin cancer. A major cause of UV light-induced damage to skin is increased free radicals, such as superoxides. Increased superoxides can cause oxidative and nitrative damage to cell components. Thus, agents that counteract these damages may have therapeutic value. Herein, we show that angiopoietin-1 (ang1) prevented and blocked H(2)O(2)-induced increases in superoxides in human spontaneously immortalized keratinocyte line, HaCaT, and… CONTINUE READING

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