Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions.

@article{Gamble2000Angiopoietin1IA,
  title={Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions.},
  author={Jennifer R. Gamble and Janice E. Drew and L Trezise and Anne Underwood and Michelle Parsons and L Kasminkas and John Rudge and George D. Yancopoulos and Mathew A. Vadas},
  journal={Circulation research},
  year={2000},
  volume={87 7},
  pages={603-7}
}
Inflammation is a basic pathological mechanism that underlies many diseases. An important component of the inflammatory response is the passage of plasma components and leukocytes from the blood vessel into the tissues. The endothelial monolayer lining blood vessels reacts to stimuli such as thrombin or vascular endothelial growth factor by changes in cell-cell junctions, an increase in permeability, and the leakage of plasma components into tissues. Other stimuli, such as tumor necrosis factor… CONTINUE READING