Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors.

@article{Stoeltzing2003Angiopoietin1IV,
  title={Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors.},
  author={Oliver Stoeltzing and Syed Ameen Ahmad and Wenbiao Liu and Marya F. McCarty and Jane S Wey and Alexander A. Parikh and Fan Fan and Niels Reinmuth and Michiya Kawaguchi and Corazon D. Bucana and Lee M. Ellis},
  journal={Cancer research},
  year={2003},
  volume={63 12},
  pages={3370-7}
}
Angiopoietin (Ang)-1 and -2 are critical regulators of embryonic and postnatal neovascularization. Ang-1 activates the endothelial cell-specific tyrosine kinase receptor Tie-2, which in turn leads to enhanced endothelial cell survival and stabilization. The effects of Ang-1 on tumor angiogenesis remain controversial; although we have previously demonstrated that Ang-1 overexpression in colon cancer cells leads to a decrease in s.c. tumor growth, others have shown that Ang-1 may be proangiogenic… CONTINUE READING
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