Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.

  title={Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.},
  author={Samuel Valable and Anita C. Bellail and Sylvain Lesn{\'e} and G{\'e}raldine Liot and Eric T Mackenzie and Denis Vivien and Myriam Bernaudin and Emmanuel Petit},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={17 3},
Although angiopoietin-1 (Ang-1) is recognized as an endothelial growth factor, its presence in brain following an ischemic event suggests a role in the evolution of neuronal damage. Using primary neuronal cultures, we showed that neurons express Ang-1 and possess the functional angiopoietin-receptor Tie-2, which is phosphorylated in the presence of Ang-1. We further investigated in vitro whether Ang-1 could protect neurons against either excitotoxic necrosis or apoptosis induced by serum… CONTINUE READING
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