Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4

@inproceedings{Burnett2017Angiopoietin1EN,
  title={Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4},
  author={Amanda Burnett and Ingrid Ximena Escobar G{\'o}mez and David Davila De Leon and Mark P. Ariaans and Pavlos Progias and Richard A. Kammerer and Guillermo Velasco and Marie Marron and Paul Hellewell and Victoria Ridger},
  booktitle={Scientific Reports},
  year={2017}
}
Angiopoietins are a family of growth factors that are ligands for the tyrosine kinase receptor, Tie2. Angiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel maturation and stability and has been shown to possess anti-inflammatory properties. However, Tie2 expression has been demonstrated on human neutrophils and the observation that neutrophils migrate in response to Ang-1 in vitro has confounded research into its exact role in inflammation as well as its potential use… CONTINUE READING

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