Angiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease.

@article{Ward2004Angiopoietin1CR,
  title={Angiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease.},
  author={Nicole Ward and Alexandra L Haninec and Paul Van Slyke and John G. Sled and Celina Sturk and R. Mark Henkelman and Ian R Wanless and Daniel J. Dumont},
  journal={The American journal of pathology},
  year={2004},
  volume={165 3},
  pages={889-99}
}
In many different liver diseases, such as cirrhosis, degradation of the microcirculation, including obliteration of small portal or hepatic veins contributes to disease-associated portal hypertension. The present study demonstrates the importance of angiogenesis in the establishment of arteriovenous shunts and the accompanying changes to the venous bed. One aspect of angiogenesis involves the branching of new vessels from pre-existing ones, and the molecular mechanisms controlling it are… CONTINUE READING